Is yellow nail syndrome an autoimmune disease?

YNS is characterized by a triad of thickened yellow nails, primary lymphedema and respiratory manifestations. It is an acquired condition of unknown etiology. It is a syndrome – not a disease – that is associated with conditions as different as diseases implicating the lymphatic system, autoimmune diseases or cancers.

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Is yellow nail syndrome serious?

No. Although yellow nail syndrome can cause serious symptoms, it isn't usually fatal.

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What autoimmune disease causes yellow nails?

Some reports in the medical literature have linked some cases of yellow nail syndrome to changes (called mutations or variants) of the FOXC2 gene. This gene is known to cause a similar disorder called lymphedema-distichiasis syndrome.

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What conditions are associated with yellow nail syndrome?

Yellow nail syndrome (YNS) is a rare condition defined by a presence of two of the following: (1) slow-growing, hard, yellow, and dystrophic nails, (2) lymphedema, and (3) respiratory tract disease. The earliest case of YNS was reported by Heller in 1927.

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What autoimmune disease affects your nails?

Nail psoriasis is an autoimmune disease that causes discoloration, pitting and changes in the structure of your nails. It can make you feel self-conscious, though you can buff your nails and apply nail polish to improve their appearance. Nail psoriasis isn't contagious, and treatments can help your symptoms improve.

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Mayo Clinic Minute: Fingernails are clues to your health

39 related questions found

Is there a cure for yellow nail syndrome?

There's no one treatment for the condition. Yellow nail syndrome treatment includes the following steps to treat specific symptoms: Administration of oral vitamin E and triazole antifungal medications to treat nail changes. Corticosteroids to relieve the symptoms.

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What age does yellow nail syndrome occur?

Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed.

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What do yellow nails say about your health?

Yellow nail syndrome is often a sign of respiratory disease, such as chronic bronchitis. Yellow nail syndrome can also be related to swelling of the hands (lymphedema).

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Does yellow nails mean diabetes?

yellow nails

The skin and nails of patients with diabetes tend to take on a yellow hue, probably due to metabolism of glucose which has become linked to protein. This hue is most evident in the nails, especially distally, but occasionally evident in the skin.

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Does vitamin D deficiency cause nail problems?

Vitamin D is necessary for the absorption of calcium, which maintains healthy bones. If your nails are peeling, brittle, or have vertical ridges, you may be vitamin D deficient.

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How do I get my yellow nails back to normal?

Treatment: There is no treatment because the staining resolves on its own with time. To speed up the process, give your nails a break from use of polish, avoid acetone nail polish removers and soak your nails in diluted hydrogen peroxide (1part peroxide, 3 parts water) to help reduce the yellowing.

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What supplements help yellow nails?

Yellow nails could also be evidence of vitamin deficiencies. Biotin, gelatin and collagen are important supplements that are often given to strengthen weak nails. A lack of any of these are usually the root cause of soft or brittle nails. Magnesium provides the protein your nail needs, critical for healthy growth.

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Are yellow nails permanent?

Do you need to worry? Blame it on the nail polish or an infection, either way, yellow nails are not a permanent condition and can be overcome using simple home remedies.

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What are signs that your liver is struggling?

If signs and symptoms of liver disease do occur, they may include:
  • Skin and eyes that appear yellowish (jaundice)
  • Abdominal pain and swelling.
  • Swelling in the legs and ankles.
  • Itchy skin.
  • Dark urine color.
  • Pale stool color.
  • Chronic fatigue.
  • Nausea or vomiting.

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What are the warning signs your liver is failing?

Signs and symptoms of acute liver failure may include:
  • Yellowing of your skin and eyeballs (jaundice)
  • Pain in your upper right abdomen.
  • A swollen belly (ascites)
  • Nausea.
  • Vomiting.
  • A general sense of feeling unwell (malaise)
  • Disorientation or confusion.
  • Sleepiness.

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What do your nails look like with liver disease?

Terry's nails is a type of nail discoloration. The nailbeds look “washed out,” except for a thin reddish-brown strip near the tip. Often, Terry's nails is a symptom of a chronic condition, such as liver failure or diabetes.

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What medications cause yellow nails?

Some drugs such as D-penicillamine, gold, thiol-containing drugs, and bucillamine can cause nail discoloration, which resolves after discontinuation [8].

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What does B12 deficiency nails look like?

2 Nail changes in vitamin B12 deficiency present as hyperpigmentation of nails like bluish discoloration of nails, blue-black pigmentation with dark longitudinal streaks, and longitudinal and reticulate darkened streaks. The nail pigmentation associated with B12 deficiency is more frequent in patients with dark skin.

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Can B12 deficiency cause yellow nails?

“In fact, vitamin B12 more commonly causes entirely blue nails, bluish-black pigments with wavy longitudinal dark streaks and/or brownish pigmentation, not yellow.”

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Can hypothyroidism cause yellow nails?

The yellow nail syndrome is rare. It associates the triad: yellow nails, lymphedema and thoracic events. We report two cases of this syndrome with major hypothyroidism.

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Why would fingernails turn yellow?

Yellowing nails is commonly due to a nail infection or fungus. Nasty, we know, but it happens! Other symptoms of a fungal infection can include flaking of the nail and an unpleasant odour. If left untreated, the nail bed could retract, causing it to thicken and crumble.

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Does apple cider vinegar help yellow nails?

The acetic and malic acids present in apple cider vinegar are responsible for reducing discolouration or yellowness of nails. Apple cider vinegar is also antifungal and hence helps keep infections at bay. If the discolouration is due to fungal infection, then apple cider is your best remedy.

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What are the 14 signs of vitamin D deficiency?

Symptoms when vitamin D is low
  • Fatigue.
  • Not sleeping well.
  • Bone pain or achiness.
  • Depression or feelings of sadness.
  • Hair loss.
  • Muscle weakness.
  • Loss of appetite.
  • Getting sick more easily.

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Can low B12 effect nails?

Vitamin-B12 deficiency can present with glossitis, pigmentary changes of nails, hairs, and skin or more serious features like megaloblastic anemia and neuropsychiatric symptoms. [2] Neuropsychiatric features, though rare, can become irreversible in severe and prolonged deficiency.

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