Fat-soluble and water-soluble vitamins For example, although it's safe to take vitamin D with vitamin B12, it's not advisable, says Virgilio Sanchez, MD, a board certified family medicine physician at Conviva Care Center in Miami, Florida.
Interactions between your drugs
No interactions were found between Vitamin B12 and Vitamin D3.
“Take water-soluble vitamins on an empty stomach with a glass of water,” recommends Dr. Perez-Gallardo. And since it can be energizing, Dr. Perez-Gallardo says that the best time to take vitamin B12 is in the morning, so it won't affect your sleep.
Taking vitamin B-12 with vitamin C might reduce the available amount of vitamin B-12 in your body. To avoid this interaction, take vitamin C two or more hours after taking a vitamin B-12 supplement.
According to health experts at Click Pharmacy, as a general rule of thumb, take your B vitamins in the morning or with a meal. Vitamin B12, for example, should definitely be taken in the morning. This is because it is important for energy metabolism, which may interrupt your sleep if taken at night.
Vitamin D and sleep: The surprising connection
Early research suggests it is inversely related to melatonin, your sleep hormone. Increasing vitamin D levels may suppress melatonin levels. So, it makes sense that taking it at night could disrupt your sleep.
As summarized in the table provided, vitamin B12 (cobalamin) absorption and utilization by the body can be compromised with the chronic use of certain medications which include: colchicine, chloramphenicol, ethanol, histamine 2 receptor antagonists (H2RA), metformin, and proton pump inhibitors (PPI).
Therefore, conditions that affect the gut and digestion, like celiac disease, chronic pancreatitis, Crohn's disease, and cystic fibrosis, can reduce vitamin D absorption.
Vitamins D, E and K
Airey says it's “simply not efficient” to take them together as your body's ability to absorb the vitamins will be reduced if you take them together.
B vitamins also help your body turn the food you eat into energy. Iron and B-complex vitamins do not interact negatively with each other, so there are no concerns about taking the two supplements at the same time.
So does vitamin B12 give you energy? While B12 doesn't directly provide energy, it does give the body the tools it needs to convert food molecules into energy. Getting the recommended daily amount of B12 can therefore help ensure that the body is able to make the energy it needs to do everything you need it to do.
There's no set time of day that's best to take vitamin D supplements. Some people say taking vitamin D supplements at night is an insomnia risk. There's no research to confirm this, but you might want to take your supplement earlier in the day if you think it's screwing with your sleep.
Can I take magnesium with other minerals and vitamins? Yes. Vitamins and minerals all work in combination and rely on each other to be fully effective. Taking magnesium helps your body to absorb and use minerals such as calcium, phosphorus and potassium, and vitamins like vitamin D.
Magnesium assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys.
If you take too much supplemental or prescription vitamin D, it can lead to vitamin D toxicity. The main complication of this is moderate to severe hypercalcemia, which can cause symptoms like vomiting, increased thirst and frequent urination.
How to Take It. If your diet includes meat, fish or shellfish, milk, and other dairy products, you should be able to meet the recommended daily requirements without taking a vitamin B12 supplement. Vegetarians who do not eat any animal products should take a vitamin B12 supplement with water, preferably after eating.
Gastric acid inhibitors include omeprazole (Prilosec®), lansoprazole (Prevacid®), cimetidine (Tagamet®), and ranitidine (Zantac®). Metformin is used to treat prediabetes and diabetes. Metformin might reduce vitamin B12 absorption and lower blood levels of vitamin B12.
Usually, vitamin B12 deficiency anemia is easy to treat with diet and vitamin supplements. To increase the amount of vitamin B12 in your diet, eat more of foods that contain it, such as: Beef, liver, and chicken. Fish and shellfish such as trout, salmon, tuna fish, and clams.
Due to its special role, vitamin B12 aids in the prevention of anemia, which mostly leads to fatigue. Even though the research available about the relationship between vitamin B12 and insomnia remains unclear, some studies² show that elevated levels of vitamin B12 do cause sleeplessness.
Vitamin B12 supplements will only improve symptoms such as tiredness and lack of energy if they are caused by low vitamin B12 levels. It may take a few weeks before your vitamin B12 levels and symptoms (such as extreme tiredness or lack of energy) start to improve.
Vitamin B12 deficiency can have distressing neuropsychiatric symptoms. It can have an etiological role in clinical presentations like depression, anxiety, psychosis, dementia, and delirium, requiring screening of at-risk populations.
Can you take vitamin D and magnesium together? Yes. In fact, it's probably best to take both together. Because so many people have low magnesium levels, vitamin D supplements on their own aren't very helpful for a large portion of the population.