What analgesics are safe for people who have kidney disease? Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin.
A gel form of the prescription NSAID diclofenac (Voltaren Gel) is one option. Only a very small amount of the drug gets into the bloodstream, so it may be safe for your kidneys. However, topicals may not work well for hip pain, because the joint is too deep for the medication to penetrate.
Study: Ibuprofen Found Safest NSAID for the Kidney.
NSAIDs disrupt the compensatory vasodilation response of renal prostaglandins to vasoconstrictor hormones released by the body [5]. Inhibition of renal prostaglandins results in acute deterioration of renal function after ingestion of NSAIDs.
But if you have a history of liver problems, it's usually recommended to avoid acetaminophen. Ibuprofen is harder on the kidneys than acetaminophen. Acetaminophen doesn't have the same effect on the COX pathway as ibuprofen. So kidney damage is much more rare.
What analgesics are safe for people who have kidney disease? Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin.
Celebrex can sometimes cause kidney problems, such as acute kidney failure and kidney stones. In clinical studies of people who took Celebrex for OA or RA, acute kidney failure occurred in less than 0.1% of the group. And kidney stones occurred in 0.1% to 1.9% of the people.
Naproxen. Another anti-inflammatory drug, which works much like ibuprofen. Some studies show this may be a better choice than ibuprofen for people at risk for heart disease.
In addition, certain supplements can help provide relief from inflammation and pain. Common alternatives to NSAIDs include arnica, curcumin, and bromelain. Topical pain reliers—like capsaicin cream—may also help to provide relief.
For people with kidney disease: If you take meloxicam for a long time, it may decrease your kidney function, making your kidney disease worse.
NSAIDs can be hard on the kidneys. But Celebrex is thought to be safer for the kidneys than ibuprofen. In one study, serum creatinine was found to be significantly increased in people treated with ibuprofen compared to Celebrex. Higher serum creatinine can mean something is wrong with your kidneys.
NSAIDs are bad for your heart and kidneys.
Long-term use of NSAIDs can make your body hold onto fluid. This can make the symptoms of heart failure, such as shortness of breath, swollen ankles, and a rapid or irregular heartbeat, worse. NSAIDs can also keep the kidneys from working well.
In general, the combination of NSAIDs and angiotensin inhibitors should be avoided. Some other preventive measures are dietary salt restriction, use of topical NSAIDs/non-pharmacological therapies and use of calcium channel blockers for treating hypertension.
NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) — such as ibuprofen and naproxen — may worsen kidney function by affecting blood flow within the kidneys, explains Dr. Vanderbleek. Any patient with chronic kidney disease should avoid long-term use of NSAIDs, says Dr. Rovin.
It reduces inflammation and pain. Voltaren gel is approved for use on arm and leg joints only. It has not been studied for use in the hips or spine. You should not use Voltaren gel to treat muscle pain in other areas of the body, such as the lower back.
Although both Celebrex and Mobic have the potential to cause cardiovascular problems, including heart attack and stroke, one study showed that Celebrex is less likely to cause cardiovascular issues than Mobic.
Common over-the-counter anti-inflammatory drugs for arthritis include ibuprofen, naproxen, and diclofenac gel.
Research shows diclofenac is the strongest and most effective non-steroidal anti-inflammatory medicine available. 10 Diclofenec is sold under the prescription brand names Cambia, Cataflam, Zipsor, and Zorvolex. It is also available as a topical gel, Voltaren, which is available over the counter.
To fight inflammation, go for whole, unprocessed foods with no added sugar: fruits, vegetables, whole grains, legumes (beans, lentils), fish, poultry, nuts, seeds, a little bit of low-fat dairy, and olive oil. "To these, many people add herbs and spices like cinnamon, ginger, and turmeric.
FDA: No CV advantage with naproxen Diclofenac at 150 mg/day is the most effective NSAID for treating osteoarthritic pain and physical disability, while paracetamol had nearly no effect.
No adverse events related to the urinary system, or increases in serum urea or potassium were recorded. The results suggest that meloxicam, 15 mg once daily, does not further compromise renal function or result in accumulation of meloxicam over this treatment period in patients with pre-existing mild renal impairment.
They're similarly effective as other NSAIDs for pain relief. Meloxicam and Celebrex are both available in generic forms. Meloxicam typically costs less than generic Celebrex, making it a more affordable option. But there are still ways to save on both medications.
As a result, the FDA made the following change to the Celebrex label: Celebrex may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction and stroke, which can be fatal. All NSAIDs may have a similar risk. This risk may increase with duration of use.