Like systemic lupus, cutaneous lupus is caused by an autoimmune response, meaning the body attacks its own tissues and organs. In cutaneous lupus, the immune system targets skin cells, causing inflammation that leads to red, thick, and often scaly rashes and sores that may burn or itch.
Scleroderma and its Effects on Skin
Scleroderma (also called systemic sclerosis), which causes the skin to thicken to a debilitating degree, has the highest mortality of any autoimmune disease: People with diffuse scleroderma (a subtype) have an average survival rate of only 10 years.
Asherson's syndrome is an extremely rare autoimmune disorder characterized by the development, over a period of hours, days or weeks, of rapidly progressive blood clots affecting multiple organ systems of the body.
The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.
Itching and rashes often occur together, but itchy skin alone can happen with dry skin, bug bites, some health conditions, or as a reaction to certain medications. The causes of skin itching, or pruritis, are usually harmless. They are often temporary issues such as dry skin or a bug bite.
If this system is not functioning well, certain cytokines can be expressed abnormally. In your case, it would appear that when you get a bit run down and as your immune system weakens, you have a tendency to histamines and it is this substance that causes you to itch.
Itching is a symptom of many health conditions. Some common causes are: Allergic reactions to food, insect bites, pollen, and medicines. Skin conditions such as eczema, psoriasis, and dry skin.
Antinuclear antibodies are markers for a number of autoimmune diseases, the most notable of which is systemic lupus erythematosus (Ferrell and Tan, 1985). Antibodies to specific nuclear constituents are high specific for certain collagen vascular diseases.
Systemic sodium channel blockers, such as carbamazepine and oxcarbazepine are the first-line choice, as they calm the ectopic neuronal firing. Gabapentin and pregabalin are commonly prescribed for patients with brachioradial pruritus and appear effective at similar concentrations as used for neuropathic pain.
Other possible symptoms of Sjögren's syndrome can include: dry, itchy skin. severe tiredness and exhaustion. vaginal dryness in women, which can make sex painful.
Disease Overview
Prurigo nodularis (PN) is a chronic inflammatory skin disease where an extremely itchy, symmetrically distributed rash appears most commonly on the arms, legs, the upper back and/or the abdomen. The itch associated with PN is so severe that it often interferes with sleep and psychological wellbeing.
does not get better with self-care or it keeps coming back. is caused by a new rash, lump or swelling that you're worried about. is all over your body – this could be a sign of something more serious.
Itching with kidney disease can be generalized, or it can occur in specific parts of the body. Common areas for this type of itching include the head, arms, back, and abdomen. It also tends to be worse at night, which can disturb your sleep.
A neuropathic itch may produce an itching sensation or a feeling of pins and needles. The itching may be very severe. Neuropathic itch may also produce the following sensations: burning.
Some common autoimmune diseases, including Type 1 diabetes mellitus, are relatively easy to diagnose, while others, such as vasculitis, Addison's disease, lupus, and other rheumatic diseases, are more difficult. Additionally, many of the 100-plus autoimmune diseases are uncommon or rare.