It's best not to drink alcohol while you're taking fexofenadine as it can make you feel sleepy. Is there any food or drink I need to avoid? Do not drink grapefruit juice, orange juice or apple juice while taking fexofenadine. It might make you more likely to have side effects.
fexofenadine food
Consuming large amounts of certain fruit juices, including grapefruit, orange and apple, may decrease the levels of fexofenadine in your body. Fexofenadine should be taken with water and refrain from drinking large amounts of grapefruit, orange, or apple juice.
Do not take this drug in higher doses or more often than prescribed. Stop taking aluminum and magnesium-containing antacids within 2 hours of taking this drug. Fexofenadine absorption can be impaired by these antacids.
Do not take antacids containing aluminum and magnesium within 2 hours of taking this medication. These antacids can decrease the absorption of fexofenadine. Tell your doctor if your condition does not improve or if it worsens.
Many fruit juices are organic anion transporting peptide (OATP) 1A2 and/or OATP2B1 inhibitors. OATP-mediated transport facilitates the intestinal absorption of fexofenadine. It is estimated that the bioavailability of fexofenadine is decreased by 36% when coadministered with grapefruit or orange juice.
Some medications for treating allergies, like Zyrtec (cetirizine) and Allegra (fexofenadine) last 24 hours and don't need to be taken at night. But if you're combating allergy symptoms with a different antihistamine first thing in the morning, keep in mind that its effects will only last six to eight hours.
H1 receptor antihistamines such as cetirizine, fexofenadine, and desloratadine are among the most commonly prescribed medications for the treatment of allergies and have been shown to stimulate appetite and weight gain as side effects of treatment (6).
Cardiac Arrythmia Risk.
Newer antihistamines like fexofenadine, ceterizine and loratadine are all fairly safe for the heart, with fexofenadine seeming to be the absolute safest if you are at risk of arrythmia.
The recommended dose is one tablet (180 mg) daily. Take your tablet with water before a meal. This medicine starts to relieve your symptoms within 1 hour and lasts for 24 hours.
Grapefruit, orange, and apple juice impair absorption of fexofenadine. Coffee? No problem. Fruit juice devotees could switch to another beverage until their congestion clears, or they might prefer to use another antihistamine in the same class—loratadine, which fruit juices do not affect.
Consumption may increase blood pressure and heart rate and can interfere with regular heart medication.
Fexofenadine use is not generally associated with liver enzyme elevations but terfenadine, a second generation antihistamine that is metabolized in part to fexofenadine, was the attributed cause of several reported cases of clinically apparent liver injury.
What foods are highest in histamine? High histamine foods include fermented foods, alcohol, aged cheeses, eggplant, avocado, citrus foods, dried fruit, legumes, and processed meats.
Fexofenadine is primarily eliminated by the kidney, and the risk of toxic reactions may be greater in patients with renal impairment due to decreased drug clearance. Care should be taken in dose selection and it may be useful to monitor renal function.
Stop using fexofenadine and pseudoephedrine and call your doctor at once if you have: pounding heartbeats or fluttering in your chest; or. severe dizziness, anxiety, restless feeling, tremors, or nervousness.
Fexofenadine is highly selective for peripheral H1-receptors and does not cross the blood–brain barrier, as shown by positron emission tomography. These data support findings that fexofenadine is nonsedating and does not impair performance or driving ability, even at very high doses.
Adults and children 12 years of age and older—60 milligrams (mg) two times a day, or 180 mg once a day. Children 6 to 11 years of age—30 mg two times a day. Children 4 to 6 years of age—Use and dose must be determined by your doctor . Children and infants up to 4 years of age—Use is not recommended .
Conclusions: These two long-term studies demonstrate that fexofenadine, at doses up to 240mg once daily for up to 12 months in healthy volunteers, is safe and well tolerated.
Fexofenadine increased both triglycerides and cholesterol ester, whereas cetirizine increased only cholesterol ester in liver, with a concomitant decrease in serum triglycerides by both antihistamines in wild-type mice.
Fexofenadine is classed as a non-drowsy antihistamine, but some people still find it makes them feel quite sleepy. Common side effects include headaches, feeling sleepy, dry mouth, feeling sick and dizziness. Do not drink grapefruit juice, apple juice or orange juice while you're taking fexofenadine.
Non-drowsy antihistamines, like fexofenadine and loratadine, the decongestant pseudoephedrine, and the cough suppressant dextromethorphan can cause anxiety or jitteriness, which can lead to insomnia.
Fexofenadine works selectively on histamine-1 receptors that are located in our body, but not in our central nervous system - these are called peripheral histamine receptors. Because it acts on these receptors, fexofenadine is much less likely to cause drowsiness compared with some older antihistamines.