Safety and side effects Oral use of glucosamine sulfate can cause: Nausea. Heartburn. Diarrhea.
It is OK to take glucosamine every day, but check with your healthcare provider. For example, with osteoarthritis, the following doses have been studied: By mouth: 1,500 milligrams (mg) per day, taken either at once, in two doses of 750 mg, or in three doses of 500 mg.
What are some common side-effects of this medication? Some side effects of Glucosamine may include stomach discomfort (e.g. nausea, passing out gas more often or heartburn), or headaches.
Glucosamine may affect blood sugar and insulin levels. However, studies are mixed. Talk to your doctor before taking this supplement if you have diabetes or insulin resistance. Animal studies show that glucosamine may further increase LDL "bad" cholesterol levels if you eat a lot of fatty foods.
A 2022 analysis of eight studies that included nearly 4,000 people with knee osteoarthritis found no convincing evidence that glucosamine and chondroitin provided major benefit. The case for these supplements protecting joint health or preventing arthritis from worsening is similarly weak.
Glucosamine and chondroitin protect cells called chondrocytes, which help maintain cartilage structure. In theory, these supplements have the potential to slow cartilage deterioration in the joints, and to reduce pain in the process.
No serious side effects have been reported in large, well-conducted studies of people taking glucosamine, chondroitin, or both for up to 3 years.
Blood and circulation issues: Glucosamine may also affect blood pressure and blood clotting. People who take it should: avoid using glucosamine with warfarin (Coumadin) and other blood thinners. monitor their blood pressure if they are using glucosamine.
Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.
Glucosamine, chondroitin, omega-3, and green tea are just a few of them. Glucosamine has been touted as an anti-inflammatory that helps keep the cartilage in joints healthy. Studies have shown some benefit for joint pain, but they are not conclusive. Natural glucosamine levels drop as people age.
Whereas glucosamine structurally supports connective tissue integrity within the joint, turmeric offers greater protection against joint-diminishing oxidative stress, inflammation, and enzymes.
Glucosamine and chondroitin are non-vitamin, non-mineral supplements which have anti-inflammatory properties. These supplements are typically used for joint pain and osteoarthritis, and are commonly taken as either glucosamine alone or as glucosamine plus chondroitin.
Glucosamine supplements have also been implicated in chronic liver disease and in worsening underlying asthma. Some patients may also experience digestive symptoms such as heartburn. The risks of other side-effects seem unclear, including whether it raises blood glucose levels in people with or without diabetes.
In fact, the American College of Rheumatology (ACR) recommends people don't take either glucosamine or chondroitin supplements for osteoarthritis.
While there is no direct evidence linking glucosamine to weight gain, some studies have suggested that it may contribute to increased appetite and calorie intake. Additionally, glucosamine supplements often contain added ingredients, such as chondroitin and MSM, which can also contribute to weight gain.
Glucosamine supplements have also been implicated in chronic liver disease and in worsening underlying asthma. Some patients may also experience digestive symptoms such as heartburn. The risks of other side-effects seem unclear, including whether it raises blood glucose levels in people with or without diabetes.
Glucosamine should be used with caution in patients with renal impairment, with monitoring of side effects and renal function (17). It is advisable to avoid use in patients with severe renal impairment and those on dialysis (16). Glucosamine is used for the relief of pain and symptoms associated with osteoarthritis.
While collagen provides structural support to the body's connective tissues, glucosamine plays a crucial role in the formation of healthy cartilage. Both collagen and glucosamine supplements have been shown to support joint health and alleviate the symptoms of osteoarthritis.
Because glucosamine products might be derived from the shells of shellfish, there is concern that the supplement could cause an allergic reaction in people with shellfish allergies. Glucosamine might worsen asthma. There's some concern that glucosamine might raise eye pressure.
Although glucosamine is unlikely to raise cholesterol levels in most people and is generally considered safe, keep in mind that, in some people, it can cause an allergic reaction, increase eye pressure, and have an anti-coagulant effect.
You can take glucosamine at any time during this that feels most convenient for you. There is some opinion that drinking in the morning is best. There are some people who like to drink them with meals.
Chondroitin is believed to enhance the shock-absorbing properties of collagen and block enzymes that break down cartilage. Like glucosamine, this supplement is thought to help cartilage retain water, keep joints lubricated, and possibly reverse cartilage loss.
Glucosamine sulphate and glucosamine hydrochloride are nutritional supplements. Animal studies have found that glucosamine can both delay the breakdown of and repair damaged cartilage. The results for the use of glucosamine for osteoarthritis are mixed and the size of the effect is modest.
Dietary Sources
There are no major food sources of glucosamine, so you must get it from supplements. Most supplements are made from chitin, the hard outer shells of shrimp, lobsters, and crabs. Other forms of glucosamine are available for people who are allergic to shellfish.