Overview. Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus.
Sjögren's syndrome can sometimes lead to complications. For example, your eyesight could be permanently damaged if the reduced tear production isn't treated. Sjögren's syndrome also increases your risk of developing non-Hodgkin lymphoma, which is a cancer of the lymph glands.
The top comorbidities in Sjögren's disease were fibromyalgia, depression, and pain. Women with Sjögren's disease had a higher relative risk of developing fibromyalgia, depression, pain, migraine, hypermobile syndrome, EDS and other rheumatic autoimmune diseases.
Are patients with Sjögren's Immunocompromised/Immunosuppressed? Not all Sjögren's patients have compromised immune systems. This specific risk factor is for those who regularly take drugs to suppress the immune system.
with common examples being systemic lupus erythematosus with Sjögren's syndrome and rheumatoid arthritis with autoimmune thyroiditis (1, 2). The combination of three or more autoimmune diseases is called multiple autoimmune syndrome (MAS) and was described for the first time in 1988 (3).
Background: Autoimmune diseases are multifactorial with environmental and heritable factors. Autoimmunity reflects an altered immune status, therefore the presence of more than one disorder is not uncommon. The coexistence of three or more autoimmune diseases in a patient constitutes multiple autoimmune syndrome (MAS).
Around 25% of patients with an autoimmune disease tend to develop additional autoimmune diseases (6). A number of factors have been thought to contribute to the development of multiple autoimmune diseases.
If Sjögren's syndrome isn't treated appropriately, significant, long-term complications could result that affect your eyes, mouth, lungs, kidneys, liver or lymph nodes — complications including blindness, significant dental destruction and non-Hodgkin lymphoma.
Global cognitive impairment in Sjögren's
Most patients experience “brain fog” symptoms, which manifest as memory lapses, forgetfulness, mental confusion, and difficulties in concentrating, organizing, or anticipating future events.
So it's common for people that have Sjogren's to have frequent infections like colds or bronchitis or sinus infections. Sometimes, they get yeast infections in their mouth, which is called thrush or they get vaginal yeast infections.
While some people experience mild discomfort, others suffer debilitating symptoms that greatly impair their ability to function. Early diagnosis and proper treatment can prevent serious complications and greatly improve quality of life.
Most people who have Sjögren's syndrome live their lives without any significant problems. However, a dry mouth means that you are more likely to have dental problems, such as tooth decay and infection. Dry eyes can also place you at risk for eye infections.
Activated aryl hydrocarbon receptor may interact with latent Epstein-Barr virus (EBV) infection, which in turn may predispose to the development of Sjögren's syndrome. It is estimated that the population is 95% positive for EBV serology.
Avoiding foods that tend to exacerbate symptoms including alcohol, caffeine, acidic foods, and spicy foods.
People with two or fewer of these signs and symptoms have a 3.8 percent chance of developing the condition. Those with three to six risk factors have a 39.9 percent chance of developing lymphoma. People with all seven risk factors have nearly a 100 percent chance of being diagnosed with lymphoma at some point.
These and previous studies suggest a model for pSS that separates the disease into several stages: 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTα; 2) amplification of local injury via the production of type 1 IFN; injury to the parotid glands, lungs, and kidneys is seen; ...
The patients with Sjogren's had an overall lower quality of sleep [8]. All of the studies in the systematic review noted that there is an increased number of nighttime awakenings in Sjogren's patients.
Patients with pSS have an increased risk of newly diagnosed depressive and/or anxiety disorders and sleep disorders that may impair their quality of life [4,13,14].
Falk: What kinds of factors can make Sjogren's worse? What is the effect, for example, of stress? Jonas: Well, like all autoimmune diseases, patients who feel stressed or are under unusual stress will often have exacerbation of their symptoms. Learning to manage that stress in your life is very important.
Overview. Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus.
The neurological complications of Sjögren's syndrome are extensive and range from cognitive difficulties, to burning toes and feet.
Asherson's syndrome is an extremely rare autoimmune disorder characterized by the development, over a period of hours, days or weeks, of rapidly progressive blood clots affecting multiple organ systems of the body.
The exact cause of autoimmune disorders is unknown. One theory is that some microorganisms (such as bacteria or viruses) or drugs may trigger changes that confuse the immune system. This may happen more often in people who have genes that make them more prone to autoimmune disorders.