Drug classes most commonly associated with aggressive ADRs are anti-epileptic drugs, antidepres- sants, immunomodulatory drugs, and benzodiazepines.
Stimulants Can Cause Aggressive Behavior
This means cocaine, methamphetamine, amphetamine and synthetics nicknamed “bath salts” and “spice.” They all cause a person to feel energetic and euphoric. The severe downside of these drugs is that they cause paranoia, aggression and even delusional behavior.
SSRIs that have been shown to help with anger include citalopram (Celexa), fluoxetine (Prozac), sertraline (Zoloft), among others. Sertraline seems to have the most supporting data. Other classes of antidepressants, like serotonin norepinephrine reuptake inhibitors (SNRIs), aren't widely used for treating anger.
Intermittent explosive disorder (IED) is a mental health condition marked by frequent impulsive anger outbursts or aggression. The episodes are out of proportion to the situation that triggered them and cause significant distress.
SSRIs are the first line of therapy for anxiety and depressive disorders and for many other clinical diagnoses. One of the most disturbing side effects that is observed is a tendency towards aggressiveness among patients receiving medications from this group, mainly during the first month of therapy.
The two most dangerous drugs of all 48 studied were the tricyclic amitriptyline (morbidity index of 345/1,000 and mortality index of 3.8/1,000) and lithium (325/1,000 and 1.3/1,000).
A 2016 review of over 70 trials found an increase in self-harm and aggression in children and adolescents taking SSRIs but not in adults. Another 2016 review of over 5,000 publications found that use of SSRIs in adults might increase the chance of self-harm or violence toward others.
Unrelenting anger can sometimes be a sign of a mental health condition. While challenges with emotional regulation can be a symptom of several conditions, Ogle indicates that anger can often relate to: anxiety disorders. depression.
Anger can be caused by a number of different things. Factors such as your personality, your coping style, your relationships, and your stress levels can all play a part in determining how much anger you experience in response to different situations and triggers.
It's common to feel irritable from time to time, but if you feel unusually irritable or irritable all the time or on edge, it is important that you talk to your doctor as it could be a symptom of a mental health condition, like depression, anxiety or bipolar disorder, or a physical condition.
Benzodiazepines (also known as tranquilizers) are the most widely prescribed type of medication for anxiety. Drugs such as Xanax (alprazolam), Klonopin (clonazepam), Valium (diazepam), and Ativan (lorazepam) work quickly, typically bringing relief within 30 minutes to an hour.
They most likely result from decreased production of serotonin—the neurotransmitter that SSRIs increase in the brain—which can lead to aggression, says psychiatrist Steven P. Levine, M.D.
These include methamphetamine, MDMA (ecstasy or Molly), LSD, and certain prescription medications. When taken in large doses, these substances can alter your mood, behavior, and even your identity. In some cases, long-term use of such drugs can result in permanent changes to one's personality.
Summary. The long-term physical effects of uncontrolled anger include increased anxiety, high blood pressure and headache. Anger can be a positive and useful emotion, if it is expressed appropriately. Long-term strategies for anger management include regular exercise, learning relaxation techniques and counselling.
Anger is a secondary emotion
Typically, we experience a primary emotion like fear, loss, or sadness first. Because these emotions create feelings of vulnerability and loss of control, they make us uncomfortable. One way of attempting to deal with these feelings is by subconsciously shifting into anger.
Anger, rage and lack of care or fear were all well documented side effects of taking the drug.
Antidepressants such as Prozac, Celexa and Zoloft are commonly prescribed for anger issues. These drugs do not specifically target anger within the body, but they do have a calming effect that can support control of rage and negative emotion.
Several studies suggest that antidepressant treatment of anger attacks in depression is safe and effective. Anger attacks disappear in 53-71% of depressed outpatients treated with antidepressants such as fluoxetine, sertraline, and imipramine.
Perhaps the most recognizable among them is Prozac (fluoxetine). It's still the best option for many people, but since it was approved by the Food and Drug Administration (FDA) in 1987, Prozac has been joined by a variety of other antidepressant medications.
Antidepressants That Are Hardest to Stop
Short-acting medications that affect serotonin include Effexor, Cymbalta, Celexa, Lexapro, Paxil, and Zoloft. Medications that take longer for the body to clear will make withdrawal less common to experience like Prozac or Trintellix.
SSRIs are usually the first choice medicine for depression because they generally have fewer side effects than most other types of antidepressant.