The causes of implantation failure are diverse and especially due to different maternal factors as uterine abnormalities, hormonal or metabolic disorders, infections, immunological factors, thrombophilias as well as other less common ones.
Unfortunately, various conditions can hamper the proper implantation of a blastocyst. In some cases, genetic disorders in the developing embryo disrupt the trypsin signal and cause a stress reaction that forces the uterus to reject the blastocyst.
Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors.
Of those fertilised eggs, around 15% will be lost before implantation begins. Of those which begin to implant, only about half will implant successfully.
In some cases, a woman may experience light spotting or cramping around the time when implantation would have occurred, but these symptoms can also be a sign of a normal menstrual cycle. One potential indicator of failed implantation is changes in basal body temperature.
Some of the uterine anomalies that can negatively affect implantation are: Mullerian malformations such as septate or T-shaped uterus. Anatomical pathologies such as synechiae, endometrial polyps or myomas.
Mental stress can lead to an increased endogenous level of epinephrine. Excessive epinephrine level may interfere with the decidual differentiation of human endometrial stromal cells and thus affect embryo implantation.
The reasons that can lead to this situation are: embryos that have been biopsied for diagnosis of a disease (PGT-M) and are all affected, embryos biopsied for chromosomal screening (PGT-A and PGT-S) and all have alterations in their chromosomes, and finally embryos that have suffered a block in their development and do ...
Early pregnancy loss can be grouped into two different categories based on when the loss happens. Sometimes the embryo just won't implant, which is still a loss for the patient, though not technically considered a miscarriage.
Stick to the same nutritionally balanced diet you were prescribed by your doctor when you started the IVF process. This should include a diet rich in proteins, fibre and vitamins. There may also be supplements you were prescribed to help in making your uterus more receptive to implantation.
Mechanistically, caffeine-induced implantation failure could be partially ascribed to delayed oviductal embryo transport, as preimplantation caffeine exposure can result in embryo retention in the isthmus of the fallopian tube [35]; this in vivo observation is consistent with previous ex vivo data showing that caffeine ...
When an embryo implants at the latter end of the six- to 10-day implantation window, it is called late implantation. More specifically, late implantation is typically defined as that which occurs between the 8th and 10th day.
The major reason why an IVF cycle is not successful is embryo quality. Many embryos are not able to implant after transfer to the uterus because they are flawed in some way. Even embryos that look good in the lab may have defects that cause them to die instead of growing.
Frozen embryo transfer is an effective means for achieving pregnancy. Problems can occur while preparing a woman for an FET. These problems include a failure to adequately thicken the uterine lining, premature ovulation, fluid accumulation in the uterine cavity and incorrect timing of a transfer.
Diminished Ovarian Reserve and/or Poor Quality Eggs
The chances of failed IVF are much higher in someone with diminished ovarian reserves. At the same time, you may have an adequate amount of eggs but have low egg quality. Egg quality is an indicator of success when creating a viable embryo.
Mental stress can lead to an increased endogenous level of epinephrine. Excessive epinephrine level may interfere with the decidual differentiation of human endometrial stromal cells and thus affect embryo implantation.
While it's unlikely that stress alone can cause infertility, stress interferes with a woman's ability to get pregnant. Research has shown that women with a history of depression are twice as likely to experience infertility. Anxiety also can prolong the time needed to achieve pregnancy.
According to our study, sperm morphology was not different in the IVF or ICSI groups. Contrary to this finding, it has been reported that cases with a low percentage of morphologically normal sperm ( < 4%), and low sperm concentration and motility are at a high risk of fertilization failure (23).
Practically, when IVF clinics treat patients, the limit is not much more than 5 days. This reflects the period of time in nature where the egg/embryo remains unattached in the fallopian tube before it moves into the uterus and starts to implant. Unless this connection to the uterus starts on time, the embryos perish.
Generally, when implantation occurs, you may experience sensitive breasts and mild abdominal cramping. If you haven't experienced these in the weeks after your embryo transfer, it may be indicative that the implantation has failed. Additionally, you may experience vaginal bleeding.
Late implantation Effect on Pregnancy Success
One research showed that a fertilized egg implanted by the 9th day had a 13% chance of failed pregnancy but an egg implanted on the 10th day had a 26% chance of the same. After the 12th day, the chances of a failed pregnancy rise to 82%.
Try to avoid caffeine during the two-week wait. 6) Avoid alcohol! Alcohol can also be harmful to your fertility and can affect your ability to conceive. It is best to avoid alcohol altogether during the two-week wait.