Avoid using melatonin if you're taking medication to control blood pressure, as it may raise blood pressure. Supplement interactions: Taking melatonin with other supplements that have sedative properties (including St. John's wort and valerian) may increase the effects and side effects of melatonin.
No interactions were found between Daily Multi-Vitamins with Minerals and melatonin. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Cautions with other medicines
antidepressants such as fluvoxamine or amitriptyline. benzodiazepines such as temazepam (for insomnia) or diazepam (for anxiety or muscle pain) medicines that lower blood pressure. nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen or diclofenac.
Possible drug interactions include: Anticoagulants and anti-platelet drugs, herbs and supplements. These types of drugs, herbs and supplements reduce blood clotting. Combining use of melatonin with them might increase the risk of bleeding.
Combined treatment of vitamin D with melatonin will accumulate the therapeutic efficacy and help to avoid high doses and long term treatment courses in chronic insomnia.
Enhanced Relaxation: Magnesium has natural muscle relaxant properties, while melatonin helps regulate the sleep-wake cycle and promote relaxation. Taking them together can enhance the overall relaxation effect, making it easier to unwind and prepare for sleep.
Zinc is shown to be involved in the production and action of melatonin and the later in turn increases the absorption of zinc. Co-supplementation of zinc and melatonin has been found to have many beneficial effect both in animal experiments and clinical study.
The current clinical consensus is that daily melatonin consumption is considered safe. However, according to a 2020 article published in Antioxidants, more research is needed to determine the correct dose and time and understand potential long-term effects.
This is not just a one-sided relationship, though: Numerous studies suggest that melatonin also benefits from its interaction with omega-3s.
It is typically safe for adults to take melatonin every night for short periods of time. Several factors affect whether an individual should take melatonin every day.
Caffeine blocks melatonin signaling/transmission [20].
There are 309 drugs known to interact with melatonin, along with 3 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 304 are moderate, and 5 are minor.
Do not use melatonin if you are pregnant or breastfeeding or have an autoimmune disorder, a seizure disorder or depression. Talk to your health care provider if you have diabetes or high blood pressure.
Interactions between your drugs
No interactions were found between melatonin and Vitamin B Complex 100.
Both B6 and B12, in particular, are thought to play a role in sound sleep, in part because both help your body produce serotonin and melatonin.
Interactions between your drugs
No interactions were found between Fish Oil and melatonin.
Interactions between your drugs
No interactions were found between melatonin and Vitamin B12. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Melatonin supplements are commonly used for sleep problems. There's no evidence that melatonin is harmful to your heart, liver, or kidneys when taken as directed. But it can lower blood pressure and make bleeding more likely, especially if you take other blood pressure or blood-thinning medications.
In several clinical trials, melatonin was found to be well tolerated and not associated with serum enzyme elevations or evidence of liver injury. Despite wide scale use, melatonin has not been convincingly linked to instances of clinically apparent liver injury.
Magnesium plays an important part in making sure all those biological clocks are ticking smoothly, while melatonin helps regulate your sleep-wake circadian rhythm. Supplements are sought as a possible way to adjust these cycles or make them more efficient.
Do not take zinc supplements and copper, iron, or phosphorus supplements at the same time. It is best to space doses of these products 2 hours apart, to get the full benefit from each dietary supplement.
Don't take zinc at the same time as iron or calcium supplements. A strong relationship exists between zinc and copper. Too much of one can cause a deficiency in the other. If you take zinc, including zinc in a multivitamin, you should also take copper.