The liver and kidney are particularly susceptible to organ toxicity as they are the sites of toxin filtration and toxin metabolic breakdown. Almost any organ or tissue in the human body can be affected by antimicrobial toxicity. The toxic effects of antimicrobial drugs, while potentially harmful are very rare.
The most poisonous part of your body is probably your liver - more specifically, the fat-soluble vitamin A that is stored there. Your liver stores it in a safe form, and releases it and its breakdown products in a controlled manner for use by your body.
These are referred as target organs of toxicity of the particular substance. The central nervous system is the target organ of toxicity most frequently involved in systemic effects. The blood circulation system, liver, kidneys, lungs and skin follow in frequency of systemic effects.
As blood passes through the liver, it breaks down substances, such as prescription or over-the-counter drugs, street drugs, alcohol, and caffeine. Our bodies naturally produce some harmful (toxic) chemicals or poisons, and those are also broken down by the liver.
Define organ toxicity. Toxicity is the degree to which a substance can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity), or an organ such as the liver (hepatotoxicity).
Not always. Many chemicals or medications can cause unseen damage to internal organs. Poisons can also cause serious changes in blood pressure or heart rhythm which cannot be detected without special equipment.
Substance overdose or acute alcohol poisoning can cause acute heart failure, acute liver failure or acute kidney injury. Environmental toxins can cause chronic respiratory failure, kidney disease or liver disease and contribute to developing degenerative brain diseases.
Your kidneys filter your blood as well, removing byproducts of digestion and other bodily processes by producing the urine that flushes them from your body.
The products which excreted from the body are amino acids, urea, uric acid, carbon dioxide, water, and ammonia. Ammonia is the primary excretory product. Ammonia is derived from the food containing proteins. It is considered as the most toxic nitrogenous waste.
One of the main ways they damage your body is by poisoning your enzymes, preventing your body from functioning properly. Your body relies on enzymes for every physiological function. When toxins damage your enzymes, they prevent the production of hemoglobin in your blood, which can accelerate aging.
Adipose tissue is a known reservoir for toxins, and ironically, these toxins may have contributed to weight gain in the first place. However, the storage of persistent organic pollutants (POPs) in adipose tissue can prevent its build-up in other organs, therefore protecting against the otherwise toxic effects of POPs.
Obviously, you must get rid of them. This is the job of the excretory system. You remove waste as a gas (carbon dioxide), as a liquid (urine and sweat), and as a solid. Excretion is the process of removing wastes and excess water from the body.
The main waste products are Urea and Uric acid. They are removed from the kidneys in the form of urine. Other waste products are excess water is removed from the skin in the form of sweat, and carbon dioxide is removed from the lungs.
Some of the specific waste products that must be excreted from the body include carbon dioxide from cellular respiration , ammonia and urea from protein catabolism, and uric acid from nucleic acid catabolism.
Kidney is the organ responsible for purification of blood. The major excretory product in humans is urea. Urea, excess water and other waste products are filtered from the blood by kidneys. Kidneys produce urine which has all these wastes and is thrown out while urination.
Liver – The major detoxifying organ
The Liver is the main organ associated with detoxification in the body. Liver identifies and neutralizes the toxins by breaking them down and eliminates the useless waste materials through bile juices or kidney.
General symptoms
feeling and being sick. diarrhoea. stomach pain. drowsiness, dizziness or weakness.
Poisoning can result in adverse effects on the kidney through a variety of mechanisms, including formation of toxic metabolites, interference with normal physiological process and, in some cases, unknown mechanisms.
This can cause vital organs to shut down. This usually starts with the kidneys. Blood pressure can drop dangerously low. This can cause less oxygen and nutrients to reach your kidneys.
The most common symptoms of poisoning include chest pain, unstable angina pectoris, ST-T wave changes, and atrial fibrillation. Rarely, ventricular fibrillation or sudden death can occur.
antidotes – these are substances that either prevent the poison from working or reverse its effects.
Types of poison
In regard to poisoning, chemicals can be divided into three broad groups: agricultural and industrial chemicals, drugs and health care products, and biological poisons—i.e., plant and animal sources. These three groups, along with a fourth category, radiation, are discussed below.
The organ systems involved include the lungs, the skin, and the digestive tract, but two organs are especially important: the liver and the kidneys. We call the process of eliminating toxins, “detoxication” or “detoxification,” which is the opposite of “intoxication.” Different tissues detoxify in varying ways.
Finally, waste products from food, the unconsumed bulk of what we eat, is removed from the body through part of the digestive system. The organs of the digestive system involved solely in solid waste removal are the rectum and the anus.