Luffy's devil fruit awakening allowed him to beat Kaido, who was considered the "Strongest Creature in the World." In his Gear 5th form, there are not many One Piece characters who can defeat him.
However, physical blows without Haki don't work on him due to his rubber body, and the only slashing-style ninjutsu Sakura is shown to know is a scalpel-like blade. With that being her only weapon to hurt Luffy with, it's likely she will lose this fight in embarrassing fashion.
It depends on how quick the fight will last. Luffy's Gears are costly and can't be maintained for long stretches of time and neither can Baryon Mode for Naruto. Due to the number of drawbacks the Baryon Mode brings, Luffy will probably clinch victory in Naruto vs. Luffy if they break those modes out.
It is evident that the only person capable of surpassing Roger is Luffy. Even though Luffy still has a lot to achieve, he is the only person who can transform the entire world.
Despite being one of the stronger entrants on this list, the One Punch Man one-off antagonist still certainly loses to One Piece's Luffy in a matchup.
Shanks is one of the Four Emperors of the Sea and certainly the strongest in their ranks right now. He possesses a bounty of over 4 billion berries right now, which is certainly the highest active pirate bounty that the fans know of. Shanks does not possess any Devil Fruit power, unlike Luffy.
After defeating Katakuri, Luffy has established himself as one of the strongest pirates in all the seas of the One Piece world. Furthermore, after his defeat to Kaido, Luffy had gotten even stronger by working on his Armament Haki skills, and he has now unlocked an advanced form of Conqueror's Haki.
While Blackbeard is eternal darkness, Luffy is the sun. Of course, eventually, Luffy will triumph over Blackbeard and he already has the power to do so. With his Awakened Devil Fruit as well as his Haki, which has been advanced in all three spheres, Luffy possesses the power to beat Blackbeard.
Conis and the rest of Skypiea witnessed Luffy completely destabilize Enel's attack. She then witnessed Luffy finally defeat Enel by punching the god straight into the golden bell.
4) Kaido. Another of the Four Emperors, Kaido, is renowned for his extraordinary stamina and power. He can turn into a huge dragon and is thought to be practically unbeatable.
Quite easily one of the toughest battles that Zoro has been in is the one that he fought against Dracule Mihawk, the man who currently holds the title of the World's Strongest Swordsman. Zoro challenged him during the Baratie arc and found out the gulf of power between him and the World's Strongest Swordsman.
Luffy fought several enemies. Yes, he triumphed many times, but at other times, he suffered humiliating defeats. Here are 5 Times Luffy emerged victoriously, and 5 times he suffered a bitter defeat.
Eclipsing Zoro in both mastery of Armament and Conqueror's Haki, Luffy proves himself stronger than Zoro overall. While Zoro does edge out a victory in terms of strength and physical endurance, Armament and Conqueror's Haki are undoubtedly the two more relevant factors here.
As such, Luffy awakened the true abilities of the Nika fruit. With its powers, Luffy was able to topple even Kaido and if he could defeat the man who was the Strongest Creature Alive, he can certainly defeat Shanks as well.
Points: Zoro 1, Law 0 Devil Fruit Roronoa Zoro is a very powerful character. He is known as one of the most powerful characters in the series and one of the series' best swordsmen; he is, by all means, probably going to surpass even Mihawk in the future.
9 Can't Beat: Luffy Has Nothing To Counter Sasuke Uchiha
Sasuke is arguably one of the strongest rivals Naruto has ever faced. Aside from his incredible hand-to-hand prowess, Sasuke is a great strategist capable of creating complex battle strategies on the fly, making it very likely he can outsmart Luffy.
Goku is already a master of many abilities and operates at a much higher level than Luffy at his most powerful. While Luffy's Gear Fifth abilities are indeed impressive, they are not equal to Son Goku's mastery.
Mortician: Sasuke was also way faster, Zoro was fast enough to keep with the teleporting Former King of Sorbet Bartholomew Kuma.