As Vecna continued to go after young victims in order to open more portals, he set his sights on Max Mayfield, since she was investigating the deaths of Chrissy and another student named Fred Benson with help from her friends (including Dustin, Steve, and her boyfriend Lucas).
Now, how does Vecna selects his victims? Using his telepathic powers, he can easily go through every memory in a person's mind. So he intentionally chooses the person with a weak state of mind and one who had a rough past, as it's easy to get control of their mind.
Vecna uses traumatic experiences to kill its prey. With Fred's past, Vecna has been tormenting Fred in the same way he tormented Chrissy, which led to her death. The last time we saw Fred was during the investigation of the park where Chrissy died, when Vecna uses this time to separate him from Nancy.
Now, the Duffer Brothers have discussed why it was necessary for Max to be Vecna's fourth victim, and that this was a decision that the pair came to fairly early on during season 4's creative process.
Ultimately, it is revealed in Stranger Things season 4's finale that the reason why Vecna was killing Hawkins teenagers was to create a massive gate that merges the Right Side Up with the Upside Down - and he specifically needed four bodies to do so.
His first victim was Chrissy Cunningham. Vecna targeted Chrissy by using her depression and eating disorder against her in his visions. Chrissy was killed in Eddie Munson's trailer, and the first gate was opened on the ceiling.
Stranger Things Star Millie Bobby Brown Cried the First Time She Saw Vecna. One of the side effects of using practical creature effects?
"Vecna seems to be actually intrigued by Nancy being able to figure him out, to be able to get this close to the truth... I think this is more Vecna's narcissistic traits that pull him to Nancy, why he wants to give her this information."
School newspaper reporter Fred Benson (Logan Riley Bruner) fled from a deadly car accident that continues to haunt him. Patrick was targeted due to his father's abuse of him. Finally, Vecna targets Max for her trauma from witnessing Billy's death and uses Barb's (Shannon Purser) death as a way to use Nancy.
Hawkins has suffered a lot of trauma over the years - not all of which is connected to Hawkins Lab and the Upside Down - and Vecna's curse takes advantage of that. Vecna appears to carefully choose people who feel a strong sense of guilt or shame, particularly if those emotions are repressed.
In the visions of her trauma induced by Vecna, Chrissy's mother appeared both mentally and emotionally abusive towards her daughter - and it's implied her comments about Chrissy's figure caused her daughter to develop her eating disorder.
(All of which have been cited by show creators the Duffer brothers as inspirations for the villain.) But he does have a surprising weakness: music.
Vecna kills Chrissy, Fred, and Patric, three characters we were just beginning to know. The villain also almost takes our beloved Max, but she is saved by the power of music! Finally, episode 7, titled “Chapter Seven: The Massacre at Hawkins Lab,” left audiences with a pretty big cliffhanger: Vecna enters Nancy's mind.
Then there were the three poor teens of Season 4. Vecna's first big credited kill was Chrissy Cunningham (Grace Van Dien). He followed that murder with canonically terrible driver Fred Benson (Logan Riley Bruner) and basketball star Patrick McKinney (Myles Truitt).
Curiously, he also seems obsessed with time, projecting strange visions into his victims' minds—including of the grandfather clock from his home in the Creel House. Vecna's obsession with time appears to be linked to his hatred of humanity.
The theory is that Karen Wheeler might be Vecna's sister, Alice Creel. As we know, Vecna is actually a man of many names, including 001, Peter Ballard and Henry Creel. We saw Henry and Alice together as children briefly in a flashback and it is believed that Henry killed his sister along with his mother.
Next up, the viewers go on to theorise that One/Vecna is actually Eleven's dad. Yep, told you it was wild. The theory claims that Brenner wanted to create a child with stronger powers, so he waited until One was old enough to become a father.
However, either she didn't have a great aim or she was trying to play it safe because she didn't hit him in the face even once, and that may be the reason why Vecna is still alive. Obviously, Nancy was trying to play it safe. She even cut off the muzzle of her shotgun so she could have the best odds.
He didn't name himself Vecna, the kids did. They named him after a DnD character who's a wizard, since Vecna's curse sounds like something a dark wizard would do.
One/Vecna had his powers blocked and was working as an aide at Hawkins National Lab where he befriended Eleven. Not knowing that One was evil, Eleven restored his powers which he used to gruesomely massacre the entire lab. Eleven banished One/Vecna to the Upside Down where he's been attacking the Hawkins teens from.
Vecna was not always a hideous beast of the Upside Down. He was once a troubled child in the real world named Henry Creel. Henry's “problems” caused his family to move to Hawkins in 1959. However, the exact issues that led to the relocation are unclear.
While caught in Vecna's grip, a tear in the dark dimension reveals her friends on the other side, desperately trying to save her from Vecna's curse. Of course, it's "Running Up That Hill," blasted into Max's headphones that breaks Vecna's hold on her.
Played by Jamie Campbell Bower, each prosthetic was glued to his skin with medical adhesive by prosthetics designer Barrie Gower and his team. For the finishing touch, Vecna was covered in "glossy slime to make him really, really glossy and wet looking," according to Gower.
After focusing on positive memories, Max braced herself and pulled at a vine in Vecna's neck, causing him to accidentally release her from the vines' grasp. As Max dashed towards the window, a disgruntled Vecna regained his composure.