Oral fungal medication does put your liver at an increase risk of damage, but when used properly the risk is minimal.
Ketoconazole should only be used to treat fungal infections when other medications are not available or cannot be tolerated. Ketoconazole may cause liver damage, sometimes serious enough to require liver transplantation or to cause death.
Nail changes are among the dermatological disorders associated with liver disease; these include onychomycosis in addition to other changes as onychorrhexis, dystrophic nails, leukonychia, longitudinal striations, brittle nails, clubbing of fingers, and longitudinal melanonychia [8].
Clinically apparent liver injury from terbinafine occurs rarely (1 in 50,000 to 120,000 prescriptions), but many case reports and even case series have been described in the literature. Liver injury usually arises within the first 6 weeks of therapy.
There is a view that oral terbinafine is a particularly dangerous medication in relation to causing hepatotoxicity (5). The most common side effects in patients taking the drug include gastro-intestinal upset, taste disturbances, headache and rashes but liver problems may not be as common as perceived.
Terbinafine is a common antifungal drug used for onychomycosis that may cause hepatotoxicity with an incidence of 0.5–3/100,000 exposed. Terbinafine cause several types of hepatotoxicity that include acute hepatitis, cholestasis or mixed picture, acute liver failure and vanishing bile duct syndrome.
Antifungal-induced hepatic injury is often characterized as an acute, cholestatic, or mixed hepatocellular-cholestatic response [1]. The reaction generally resolves with discontinuation of treatment, but some liver damage can be chronic.
Toenail fungus doesn't usually spread to inside your body, like the stomach. The fungi require keratin, found in your hair, skin and nails. They survive best on the skin.
The route of the liver meridian: starts at the inside (lateral) edge of the big toe, runs on top of the foot, front of ankle, inner calf and thigh to pubic area, into the stomach, liver and gallbladder. Eventually, it connects with the lung meridian, the throat, the eyes, and crown of the head.
Antifungal drug-induced liver injury is most commonly reported with voriconazole (32.45%), fluconazole (19.37%), and itraconazole (14.51%).
Fluconazole and itraconazole are considered safe drugs that occasionally have been associated with slight alterations of liver function tests that usually do not require interruption of treatment.
In rare cases, toenail fungus can cause an infection called cellulitis. Without prompt treatment, cellulitis may pose a serious danger to your health.
If toenail fungus is left untreated, it can spread to the surrounding skin on the foot, causing another condition known as athlete's foot. An athlete's foot is a condition resulting in itchy, red, and cracked skin, which can become very uncomfortable.
There are multiple treatments for toenail fungus, though some are faster than others. The fastest way to eliminate the infection is through toenail laser treatment.
While a skin or nail fungus can easily spread from one body part to another or from one person to another via contact, it's extremely rare for a toenail fungus itself to spread internally.
Eventually, involvement of the liver is possible in the endemic fungal infections, such as blastomycosis, coccidioidomycosis, and histoplasmosis, whereas hepatic pneumocystosis has been reported exclusively in HIV-infected individuals.
The researchers' experiments showed that fungi contribute to alcoholic liver disease in the following way: The fungi release a sugar called beta-glucan and this sugar moves out of the intestine and into surrounding organs, including the liver.
Bacterial and fungal infections (BFIs) are frequent in patients with cirrhosis and often trigger acute-on-chronic liver failure (ACLF). This prospective observational study aims to describe the interactions between BFI and ACLF in terms of mortality and related risk factors.
Fungal nail infections: Fungal nail infections usually take longer to heal than fungal skin infections. You will usually take the tablets for anywhere from 6 weeks to 3 months. But, if you have a nail infection of the big toe or your nails grow very slowly, you may need to take the tablets for up to 6 months.
This medicine may cause serious liver problems, including liver failure. Check with your doctor right away if you start having nausea or vomiting, dark urine, light-colored stools, stomach pain, or yellow eyes or skin while you or your child are using this medicine.
If my patient is on SSKI, I want to see a thyrotopin level (TSH) after two months. If I'm treating a patient for onychomycosis with terbinafine for a standard 12-week course, I routinely check a complete blood count (CBC) and liver function tests (LFTs) at baseline and at six weeks.