Stopping exposure to the toxic agent is the first line of treatment for liver toxicity. Other forms of treatment include medications, supportive therapy, and emergency care. In rare cases, a liver transplant may be necessary.
Usually, drug induced liver injury starts to resolve within a few days to a week of stopping therapy. In some instances, the resolution is quite rapid (acetaminophen, niacin), but in most cases, the injury does not fully resolve for several weeks or months.
Early Signs of Liver Damage from Medication
Fever. Diarrhea. Dark urine. Jaundice, a condition that occurs when a substance called bilirubin builds up in the blood and causes the skin and whites of the eyes to appear yellow.
The liver, however, is able to replace damaged tissue with new cells. If up to 50 to 60 percent of the liver cells may be killed within three to four days in an extreme case like a Tylenol overdose, the liver will repair completely after 30 days if no complications arise.
Acetaminophen. Taking acetaminophen in excess is the leading cause of drug-induced liver injury.
Increased appetite: Digesting foods and nutrients can become easier as the liver healing continues. Usually, your appetite can improve as well. Improved blood work: Liver healing can lower toxin levels in your blood and improve liver function. You can see evidence of these improvements in your lab work.
You will experience physical signs your liver is healing, such as healthier-looking skin and eyes, increased energy levels, and reduced stomach pain and swelling. Other signs your liver is healing include: Improved amino-acid regulation – Your liver processes proteins and amino acids that your body cannot store.
Pain in your liver itself can feel like a dull throbbing pain or a stabbing sensation in your right upper abdomen just under your ribs. General abdominal pain and discomfort can also be related to swelling from fluid retention and enlargement of your spleen and liver caused by cirrhosis.
Stage 1: Inflammation
In the early stages of liver disease, the liver will become swollen or inflamed as the body's natural response to injury. Liver inflammation, or hepatitis, can also occur when there are more toxins in the blood than the liver is able to manage. The earlier the diagnosis, the better.
As the liver becomes more severely damaged, more obvious and serious symptoms can develop, such as: yellowing of the skin or whites of the eyes (jaundice) swelling in the legs, ankles and feet caused by a build-up of fluid (oedema) swelling in your abdomen caused by a build-up of fluid known as ascites.
The liver is very resilient and capable of regenerating itself. Each time your liver filters alcohol, some of the liver cells die. The liver can develop new cells, but prolonged alcohol misuse (drinking too much) over many years can reduce its ability to regenerate.
In many cases, liver enzyme levels return to normal on their own within about a month. You might need to switch medications, stop taking a supplement, or cut back on drinking if you drink, but you will not need a treatment plan.
Liver failure occurs when your liver isn't working well enough to perform its functions (for example, manufacturing bile and ridding your body of harmful substances). Symptoms include nausea, loss of appetite, and blood in the stool. Treatments include avoiding alcohol and avoiding certain foods.
Nonprescription pain relievers such as acetaminophen (Tylenol, others), aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen (Aleve, others) can damage your liver, especially if taken frequently or combined with alcohol.
There are at-home liver panel tests that can determine liver function by screening for proteins and enzymes like albumin, globulin, ALP, ALT, and GGT. These tests use a finger-prick sample and include materials to collect and send your specimen to the lab. You can order a liver panel from home and get tested in a lab.
Pain in your upper right abdomen. A swollen belly (ascites) Nausea. Vomiting.
At first, you probably won't notice liver problems. But as it gets worse, your skin can feel itchy and bruise easily. Your eyes and skin may look yellowish, which doctors call jaundice. Your belly might hurt, and you could lose your appetite or feel sick to your stomach.
The liver damage done by cirrhosis generally can't be undone. But if liver cirrhosis is diagnosed early and the cause is treated, further damage can be limited and, rarely, reversed.