Global cognitive impairment in Sjögren's Most patients experience “brain fog” symptoms, which manifest as memory lapses, forgetfulness, mental confusion, and difficulties in concentrating, organizing, or anticipating future events.
“Brain fog” is a colloquial term for cognitive dysfunction, which refers to impairment in functions such as thinking, memory, and reasoning in a way that can affect daily activities. It is a common complaint among people with Sjogren's syndrome.
In seizure disorders, paroxysmal and irregular bursts of electrical activity in brain nerves may lead to propagation of seizures. Similarly, in Sjögren's neuropathy, irritative electrical signals produced by nerves in the skin instead of the brain, may similarly contribute to pain.
In multivariate analysis adjusted by age groups, gender and the comorbidities, the HR of developing dementia was 1.246 (95% CI 1.123–1.384) times greater in the pSS group than in the non‐pSS group. This result suggested that pSS was an independent risk factor for the development of dementia.
Sjogren's Syndrome patients often complain of mental fatigue or “brain fog.” Brain fog impairs focus, causes fuzzy concentration, and contributes to difficulty in problem-solving. Keep your stress levels low, and give your brain a workout with crosswords, puzzles, reading, adult coloring books, or online brain games.
It may include forgetfulness, spaciness, confusion, decreased ability to pay attention, an inability to focus, and difficulty in processing information.
Overview. Sjogren's (SHOW-grins) syndrome is a disorder of your immune system identified by its two most common symptoms — dry eyes and a dry mouth. The condition often accompanies other immune system disorders, such as rheumatoid arthritis and lupus.
Primary Sjögren syndrome occurs in the absence of another underlying rheumatic disorder, whereas secondary Sjögren syndrome is associated with another underlying rheumatic disease, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or scleroderma.
Sjögren's syndrome (SS) is a chronic inflammatory disease with an autoimmune background with possible complications from peripheral (PNS) and central nervous system (CNS). The aim of this study was to assess the prevalence and to describe the phenotype of peripheral neuropathies in patients with SS.
MRI of patients with primary Sjögren syndrome has shown multiple areas of increased signal intensity in the periventricular and subcortical white matter (WM) on FLAIR and T2-weighted images [7–10]. These findings have been observed in both patients with and those without CNS impairment [7–10].
While some people experience mild discomfort, others suffer debilitating symptoms that greatly impair their ability to function. Early diagnosis and proper treatment can prevent serious complications and greatly improve quality of life.
Patients with primary Sjögren's Syndrome (pSS) have diminished health quality and fatigue, arthralgia along with dryness of the mouth and eyes have major impact on their psychological and social aspects of life.
Neurological involvement has been reported in up to 80% of adults with Primary Sjogren's syndrome (pSS) with psychiatric abnormalities including anxiety, depression, and cognitive dysfunction being common.
Liability to multiple sclerosis and Sjogren's syndrome could be associated with Alzheimer's disease.
These and previous studies suggest a model for pSS that separates the disease into several stages: 1) initial injury to the submandibular and lacrimal glands via an environmental insult and LTα; 2) amplification of local injury via the production of type 1 IFN; injury to the parotid glands, lungs, and kidneys is seen; ...
In most people with Sjögren syndrome, dry eyes and dry mouth are the primary features of the disorder, and general health and life expectancy are largely unaffected. However, in some cases the immune system also attacks and damages other organs and tissues. This complication is known as extraglandular involvement.
However, in the case of Sjogren's syndrome your immune system attacks the glands that make tears and saliva. This prevents the glands from working properly and causes dryness of the mouth, eyes or other tissues. The condition may progress slowly, so the typical symptoms of dry eyes and mouth may take years to show.
The more common symptoms of Sjogren's syndrome include: dry eyes (irritation, feeling gritty or itchy, burning) dry mouth (or difficulty chewing or swallowing).
There are several infectious agents that are suspected to play significant roles in the development of SS, such as cytomegalovirus (CMV), Epstein–Barr virus, hepatitis C virus, human T-cell lymphotropic virus-1 (HTLV-1), Staphylococcus saccharolyticus, and Heliobacter pylori (Table 2).
Dry eyes, corneal ulcerations and infections. Dry nose, recurrent sinusitis, nosebleeds. Dry mouth, mouth sores, dental decay, difficulty with chewing, speech, taste and dentures. Swollen, painful parotid/salivary glands.
Sjogren's syndrome is a chronic autoimmune disorder in which the body's own immune system attacks the glands that produce tears and saliva. Foods that help are omega-3 fatty acids, organic meat, whole fruits and vegetables. Bad foods include trans fat, high glycemic, red meat, dairy, and artificial sweeteners.
The patients with Sjogren's had an overall lower quality of sleep [8]. All of the studies in the systematic review noted that there is an increased number of nighttime awakenings in Sjogren's patients.